Question by : Does painkillers and antidepressants could affect from function normal at work? I started taking pain medications about 6 months ago and also antidepressants at the same time. I was taking Lortab 10/500 every 4 hours plus Xanax 0.5 mg twice a day plus Cimbalta 60 mg once a day plus Zanaflex supposed to be 2 a day but I would take it at night only because make me feel so tired….but my Doctor change the Lortabs to “Percocet” but I think it was to much for my body that I had to go to the ER because I felt worse…..my Dr changed to Norco 10/325. And on my last Dr. Appointment I told him I was still on pain and he gave me also (Morphin Sul 15 mg every 12 hrs…. I am sorry I forgot to mention what is my medical condition: I suffer with “Isthmic Spondylolisthesis” which my Dr is doing all the test needed for surgery because my body is not responding to all the alternative treatments I had so far 5 epidural injections 3 cervical and 2 lum ...